Amino Acids of Conserved Kinase Motifs of Cytomegalovirus Protein UL97 Are Essential for Autophosphorylation

Thirteen point mutations targeting predicted domains conserved in homologous protein kinases were introduced into the UL97 coding region of the human cytomegalovirus. All mutagenized proteins were expressed in cells infected with recombinant vaccinia viruses (rVV). Several mutations drastically redu...

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Main Authors: Michel, Detlef, Kramer, Silke, Höhn, Simone, Schaarschmidt, Peter, Wunderlich, Kirsten, Mertens, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC112917/
https://ncbi.nlm.nih.gov/pubmed/10482650
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