Casein Kinase 2-Mediated Phosphorylation of Respiratory Syncytial Virus Phosphoprotein P Is Essential for the Transcription Elongation Activity of the Viral Polymerase; Phosphorylation by Casein Kinase 1 Occurs Mainly at Ser(215) and Is without Effect

The major site of in vitro phosphorylation by casein kinase 2 (CK2) was the conserved Ser(232) in the P proteins of human, bovine, and ovine strains of respiratory syncytial virus (RSV). Enzymatic removal of this phosphate group from the P protein instantly halted transcription elongation in vitro....

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Dupuy, Lesley C., Dobson, Sean, Bitko, Vira, Barik, Sailen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112856/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10482589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.10.8384-8392.1999
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