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Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

BACKGROUND: Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on non-nuclear genes and its effect on the interferon pathway remain unexplored. Since directed mutation of RNA genomes is...

詳細記述

保存先:
書誌詳細
主要な著者: Bitko, Vira, Barik, Sailen
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC64570/
https://ncbi.nlm.nih.gov/pubmed/11801185
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