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Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells

ABSTRACT Antiviral immunity in insects and plants is mediated by the RNA interference (RNAi) pathway in which viral long double-stranded RNA (dsRNA) is processed into small interfering RNAs (siRNAs) by Dicer enzymes. Although this pathway is evolutionarily conserved, its involvement in antiviral def...

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Principais autores: Susan Schuster, Lotte E. Tholen, Gijs J. Overheul, Frank J. M. van Kuppeveld, Ronald P. van Rij
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017-08-01
Serier:mSphere
Fag:
RNA interference
RNA virus
innate immunity
Online adgang:https://journals.asm.org/doi/10.1128/mSphere.00333-17
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