Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication

The gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) promotes virus entry by sequentially binding CD4 and chemokine receptors on the target cell. Primary, clinical HIV-1 isolates require interaction with CD4 to allow gp120 to bind the CCR5 chemokine receptor efficiently...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kolchinsky, Peter, Mirzabekov, Tajib, Farzan, Michael, Kiprilov, Enko, Cayabyab, Mark, Mooney, Larissa J., Choe, Hyeryun, Sodroski, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC112828/
https://ncbi.nlm.nih.gov/pubmed/10482561
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