Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication

The gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) promotes virus entry by sequentially binding CD4 and chemokine receptors on the target cell. Primary, clinical HIV-1 isolates require interaction with CD4 to allow gp120 to bind the CCR5 chemokine receptor efficiently...

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Bibliographic Details

Published in:	J Virol
Main Authors:	Kolchinsky, Peter, Mirzabekov, Tajib, Farzan, Michael, Kiprilov, Enko, Cayabyab, Mark, Mooney, Larissa J., Choe, Hyeryun, Sodroski, Joseph
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1999
Subjects:	Virus-Cell Interactions
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10482561/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.10.8120-8126.1999
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