Adenovirus-Mediated Gene Expression In Vivo Is Enhanced by the Antiapoptotic Bcl-2 Gene

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was ob...

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Detalhes bibliográficos
Main Authors: Bilbao, Guadalupe, Contreras, Juan L., Zhang, Huang-Ge, Pike, M. Joyce, Overturf, Ken, Mikheeva, Galina, Krasnykh, Victor, Curiel, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112785/
https://ncbi.nlm.nih.gov/pubmed/10400798
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