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The H Gene of Rodent Brain-Adapted Measles Virus Confers Neurovirulence to the Edmonston Vaccine Strain

Molecular determinants of neuropathogenesis have been shown to be present in the hemagglutinin (H) protein of measles virus (MV). An H gene insertion vector has been generated from the Edmonston B vaccine full-length infectious clone of MV. Using this vector, it is possible to insert complete H open...

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Published in:J Virol
Main Authors: Duprex, W. Paul, Duffy, Iain, McQuaid, Stephen, Hamill, Louise, Cosby, S. Louise, Billeter, Martin A., Schneider-Schaulies, Jürgen, ter Meulen, Volker, Rima, Bert K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1999
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112776/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10400789/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.8.6916-6922.1999
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