The P236L Delavirdine-Resistant Human Immunodeficiency Virus Type 1 Mutant Is Replication Defective and Demonstrates Alterations in both RNA 5′-End- and DNA 3′-End-Directed RNase H Activities

The nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) delavirdine (DLV) selects in vitro for the human immunodeficiency virus type 1 (HIV-1) RT mutation P236L, which confers high-level resistance to DLV but not other NNRTIs. Unexpectedly, P236L has developed infrequently in HIV-1 isolates o...

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Vydáno v:	J Virol
Hlavní autoři:	Gerondelis, Peter, Archer, Richard H., Palaniappan, Chockalingam, Reichman, Richard C., Fay, Philip J., Bambara, Robert A., Demeter, Lisa M.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1999
Témata:	Vaccines and Antiviral Agents
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112641/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364332/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5803-5813.1999
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