Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer

We describe an improved genetic immunization strategy for eliciting a full spectrum of anti-hepatitis C virus (HCV) envelope 2 (E2) glycoprotein responses in mammals through electrical gene transfer (EGT) of plasmid DNA into muscle fibers. Intramuscular injection of a plasmid encoding a cross-reacti...

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Main Authors: Zucchelli, Silvia, Capone, Stefania, Fattori, Elena, Folgori, Antonella, Di Marco, Annalise, Casimiro, Danilo, Simon, Adam J., Laufer, Ralph, La Monica, Nicola, Cortese, Riccardo, Nicosia, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC112441/
https://ncbi.nlm.nih.gov/pubmed/11090158
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