A Novel Adenovirus Type 6 (Ad6)-Based Hepatitis C Virus Vector That Overcomes Preexisting Anti-Ad5 Immunity and Induces Potent and Broad Cellular Immune Responses in Rhesus Macaques

Success in resolving hepatitis C virus (HCV) infection has been correlated to vigorous, multispecific, and sustained CD8(+) T-cell response in humans and chimpanzees. The efficacy of inducing T-cell-mediated immunity by recombinant serotype 5 adenovirus vector has been proven in many animal models o...

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Détails bibliographiques
Auteurs principaux: Capone, Stefania, Meola, Annalisa, Ercole, Bruno Bruni, Vitelli, Alessandra, Pezzanera, Monica, Ruggeri, Lionello, Davies, Mary Ellen, Tafi, Rosalba, Santini, Claudia, Luzzago, Alessandra, Fu, Tong-Ming, Bett, Andrew, Colloca, Stefano, Cortese, Riccardo, Nicosia, Alfredo, Folgori, Antonella
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367169/
https://ncbi.nlm.nih.gov/pubmed/16439526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.4.1688-1699.2006
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