Persistent HCV replication despite priming of functional CD8+ T cells by combined therapy with a vaccine and direct acting antiviral

Exhaustion of antiviral CD8+ T cells contributes to persistence of hepatitis C virus infection. This immune response has proved difficult to restore by therapeutic vaccination, even when HCV replication is suppressed using antiviral regimens containing type I interferon (IFN). Because immunomodulato...

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Pubblicato in:Hepatology
Autori principali: Callendret, Benoit, Eccleston, Heather B., Satterfield, William, Capone, Stefania, Folgori, Antonella, Cortese, Riccardo, Nicosia, Alfredo, Walker, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840073/
https://ncbi.nlm.nih.gov/pubmed/26513111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28309
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