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A Monomeric GTPase-Negative MxA Mutant with Antiviral Activity

MxA is a large, interferon-induced GTPase with antiviral activity against RNA viruses. It forms large oligomers, but whether oligomerization and GTPase activity are important for antiviral function is not known. The mutant protein MxA(L612K) carries a lysine-for-leucine substitution at position 612...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Janzen, Christian, Kochs, Georg, Haller, Otto
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC112356/
https://ncbi.nlm.nih.gov/pubmed/10933733
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