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A Monomeric GTPase-Negative MxA Mutant with Antiviral Activity

MxA is a large, interferon-induced GTPase with antiviral activity against RNA viruses. It forms large oligomers, but whether oligomerization and GTPase activity are important for antiviral function is not known. The mutant protein MxA(L612K) carries a lysine-for-leucine substitution at position 612...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Janzen, Christian, Kochs, Georg, Haller, Otto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2000
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112356/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10933733/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.17.8202-8206.2000
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