Effect of Coexpression of Interleukin-2 by Recombinant Respiratory Syncytial Virus on Virus Replication, Immunogenicity, and Production of Other Cytokines

We constructed rRSV/mIL-2, a recombinant respiratory syncytial virus (rRSV) containing the coding sequence of murine interleukin-2 (mIL-2) in a transcription cassette inserted into the G-F intergenic region. The recovered virus (rRSV/mIL-2) expressed high levels (up to 2.8 μg/ml) of mIL-2 in cell cu...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Bukreyev, Alexander, Whitehead, Stephen S., Prussin, Calman, Murphy, Brian R., Collins, Peter L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10888656/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.15.7151-7157.2000
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