Effect of Coexpression of Interleukin-2 by Recombinant Respiratory Syncytial Virus on Virus Replication, Immunogenicity, and Production of Other Cytokines

We constructed rRSV/mIL-2, a recombinant respiratory syncytial virus (rRSV) containing the coding sequence of murine interleukin-2 (mIL-2) in a transcription cassette inserted into the G-F intergenic region. The recovered virus (rRSV/mIL-2) expressed high levels (up to 2.8 μg/ml) of mIL-2 in cell cu...

Full description

Bibliographic Details

Published in:	J Virol
Main Authors:	Bukreyev, Alexander, Whitehead, Stephen S., Prussin, Calman, Murphy, Brian R., Collins, Peter L.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2000
Subjects:	Pathogenesis and Immunity
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10888656/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.15.7151-7157.2000
Tags:	Add Tag No Tags, Be the first to tag this record!