A Single Intramuscular Injection of Recombinant Plasmid DNA Induces Protective Immunity and Prevents Japanese Encephalitis in Mice

Plasmid vectors containing Japanese encephalitis virus (JEV) premembrane (prM) and envelope (E) genes were constructed that expressed prM and E proteins under the control of a cytomegalovirus immediate-early gene promoter. COS-1 cells transformed with this plasmid vector (JE-4B clone) secreted JEV-s...

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Main Authors: Chang, Gwong-Jen J., Hunt, Ann R., Davis, Brent
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC111940/
https://ncbi.nlm.nih.gov/pubmed/10756038
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