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The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis

Nucleoside analog chain terminators such as 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxy-3′-thiacytidine (3TC) represent an important class of drugs that are used in the clinic to inhibit the reverse transcriptase (RT) of human immunodeficiency virus type 1. Recent data have suggested that mut...

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Udgivet i:J Virol
Principais autores: Götte, Matthias, Arion, Dominique, Parniak, Michael A., Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111867/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729133/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3579-3585.2000
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