Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not p...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Deonarain, Raj, Alcamí, Antonio, Alexiou, Maria, Dallman, Margaret J., Gewert, Dirk R., Porter, Andrew C. G.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111842/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10708458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.7.3404-3409.2000
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