Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not p...

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Hlavní autoři: Deonarain, Raj, Alcamí, Antonio, Alexiou, Maria, Dallman, Margaret J., Gewert, Dirk R., Porter, Andrew C. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC111842/
https://ncbi.nlm.nih.gov/pubmed/10708458
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