Efficient Gene Transfer into Human CD34(+) Cells by a Retargeted Adenovirus Vector

Efficient infection with adenovirus (Ad) vectors based on serotype 5 (Ad5) requires the presence of coxsackievirus-adenovirus receptors (CAR) and α(v) integrins on cells. The paucity of these cellular receptors is thought to be a limiting factor for Ad gene transfer into hematopoietic stem cells. In...

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Pubblicato in:	J Virol
Autori principali:	Shayakhmetov, Dmitry M., Papayannopoulou, Thalia, Stamatoyannopoulos, George, Lieber, André
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Gene Therapy
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111745/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10684271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.6.2567-2583.2000
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