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Efficient Gene Transfer into Human CD34(+) Cells by a Retargeted Adenovirus Vector

Efficient infection with adenovirus (Ad) vectors based on serotype 5 (Ad5) requires the presence of coxsackievirus-adenovirus receptors (CAR) and α(v) integrins on cells. The paucity of these cellular receptors is thought to be a limiting factor for Ad gene transfer into hematopoietic stem cells. In...

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Bibliographic Details
Main Authors: Shayakhmetov, Dmitry M., Papayannopoulou, Thalia, Stamatoyannopoulos, George, Lieber, André
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC111745/
https://ncbi.nlm.nih.gov/pubmed/10684271
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