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Split-Intron Retroviral Vectors: Enhanced Expression with Improved Safety

The inclusion of retrovirus-derived introns within retrovirus-based expression vectors leads to a fraction of the resulting transcripts being spliced. Such splicing has been shown to markedly improve expression (W. J. Krall et al., Gene Ther. 3:37–48, 1996). One way to improve upon this still furthe...

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Udgivet i:J Virol
Principais autores: Ismail, Said I., Kingsman, Susan M., Kingsman, Alan J., Uden, Mark
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111718/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10666267/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.5.2365-2371.2000
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