Mutagenesis of the Signal Sequence of Yellow Fever Virus prM Protein: Enhancement of Signalase Cleavage In Vitro Is Lethal for Virus Production

Proteolytic processing at the C-prM junction in the flavivirus polyprotein involves coordinated cleavages at the cytoplasmic and luminal sides of an internal signal sequence. We have introduced at the COOH terminus of the yellow fever virus (YFV) prM signal sequence amino acid substitutions (VPQAQA...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lee, Eva, Stocks, Christine E., Amberg, Sean M., Rice, Charles M., Lobigs, Mario
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10590087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.1.24-32.2000
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