Mutagenesis of the Signal Sequence of Yellow Fever Virus prM Protein: Enhancement of Signalase Cleavage In Vitro Is Lethal for Virus Production

Proteolytic processing at the C-prM junction in the flavivirus polyprotein involves coordinated cleavages at the cytoplasmic and luminal sides of an internal signal sequence. We have introduced at the COOH terminus of the yellow fever virus (YFV) prM signal sequence amino acid substitutions (VPQAQA...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Lee, Eva, Stocks, Christine E., Amberg, Sean M., Rice, Charles M., Lobigs, Mario
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2000
Onderwerpen:	Replication
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10590087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.1.24-32.2000
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