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Reduction of GC → TA Transversion Mutation by Overexpression of MutS in Escherichia coli K-12

Overexpression of the MutS repair protein significantly decreased the rate of lacZ GC → TA transversion mutation in stationary-phase and exponentially growing bacteria and in mutY and mutM mutants, which accumulate mismatches between 8-oxoguanine (8-oxoG) and adenine residues in DNA. Conversely, GC...

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Udgivet i:J Bacteriol
Principais autores: Zhao, Jingyong, Winkler, Malcolm E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111390/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10940054/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.17.5025-5028.2000
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