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Reduction of GC → TA Transversion Mutation by Overexpression of MutS in Escherichia coli K-12

Overexpression of the MutS repair protein significantly decreased the rate of lacZ GC → TA transversion mutation in stationary-phase and exponentially growing bacteria and in mutY and mutM mutants, which accumulate mismatches between 8-oxoguanine (8-oxoG) and adenine residues in DNA. Conversely, GC...

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Detalhes bibliográficos
Main Authors: Zhao, Jingyong, Winkler, Malcolm E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC111390/
https://ncbi.nlm.nih.gov/pubmed/10940054
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