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Reduction of GC → TA Transversion Mutation by Overexpression of MutS in Escherichia coli K-12
Overexpression of the MutS repair protein significantly decreased the rate of lacZ GC → TA transversion mutation in stationary-phase and exponentially growing bacteria and in mutY and mutM mutants, which accumulate mismatches between 8-oxoguanine (8-oxoG) and adenine residues in DNA. Conversely, GC...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2000
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC111390/ https://ncbi.nlm.nih.gov/pubmed/10940054 |
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