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Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases

The oxidation and deamination of 5-methylcytosine (5mC) in DNA generates a base-pair between 5-hydroxymethyluracil (5hmU) and guanine. 5hmU normally forms a base-pair with adenine. Therefore, the conversion of 5mC to 5hmU is a potential pathway for the generation of 5mC to T transitions. Mammalian c...

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Detalhes bibliográficos
Main Authors: Hori, Masaki, Yonei, Shuji, Sugiyama, Hiroshi, Kino, Katsuhito, Yamamoto, Kazuo, Zhang, Qiu-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150241/
https://ncbi.nlm.nih.gov/pubmed/12582238
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