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Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases

The oxidation and deamination of 5-methylcytosine (5mC) in DNA generates a base-pair between 5-hydroxymethyluracil (5hmU) and guanine. 5hmU normally forms a base-pair with adenine. Therefore, the conversion of 5mC to 5hmU is a potential pathway for the generation of 5mC to T transitions. Mammalian c...

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Udgivet i:Nucleic Acids Res
Principais autores: Hori, Masaki, Yonei, Shuji, Sugiyama, Hiroshi, Kino, Katsuhito, Yamamoto, Kazuo, Zhang, Qiu-Mei
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150241/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12582238/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg223
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