Effect of Polypurine Tract (PPT) Mutations on Human Immunodeficiency Virus Type 1 Replication: a Virus with a Completely Randomized PPT Retains Low Infectivity

We introduced polypurine tract (PPT) mutations, which we had previously tested in an in vitro assay, into the viral clone NL4-3KFSΔnef. Each mutant was tested for single-round infectivity and virion production. All of the PPT mutations had an effect on replication; however, mutation of the 5′ end ap...

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Detalhes bibliográficos
Main Authors: Miles, Lesa R., Agresta, Beth E., Khan, Mahfuz B., Tang, Shixing, Levin, Judith G., Powell, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112125/
https://ncbi.nlm.nih.gov/pubmed/15890925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.6859-6867.2005
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