Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

This study concerns chimeric restriction enzymes that are hybrids between a zinc finger DNA-binding domain and the non-specific DNA-cleavage domain from the natural restriction enzyme FokI. Because of the flexibility of DNA recognition by zinc fingers, these enzymes are potential tools for cleaving...

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Bibliographic Details
Main Authors: Smith, Jeff, Bibikova, Marina, Whitby, Frank G., Reddy, A. R., Chandrasegaran, Srinivasan, Carroll, Dana
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC110700/
https://ncbi.nlm.nih.gov/pubmed/10954606
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