Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage

Amplification of genes involved in signal transduction and cell cycle control occurs in a significant fraction of human cancers. Loss of p53 function has been proposed to enable cells with gene amplification to arise spontaneously during growth in vitro. However, this conclusion derives from studies...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Paulson, Thomas G., Almasan, Alexandru, Brody, Linnea L., Wahl, Geoffrey M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 1998
נושאים:
DNA Dynamics and Chromosome Structure
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC110691/
https://ncbi.nlm.nih.gov/pubmed/9566927
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