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DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell Line

The development of genomic instability is an important step in generating the multiple genetic changes required for cancer. One consequence of genomic instability is the overexpression of oncogenes due to gene amplification. One mechanism for gene amplification is the breakage/fusion/bridge (B/F/B)...

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Detalhes bibliográficos
Main Authors: Lo, Anthony W I, Sabatier, Laure, Fouladi, Bijan, Pottier, Géraldine, Ricoul, Michelle, Murnane, John P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1503667/
https://ncbi.nlm.nih.gov/pubmed/12407447
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