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Dimerization by Translation Initiation Factor 2 Kinase GCN2 Is Mediated by Interactions in the C-Terminal Ribosome-Binding Region and the Protein Kinase Domain

The protein kinase GCN2 stimulates translation of the transcriptional activator GCN4 in yeast cells starved for amino acids by phosphorylating translation initiation factor 2. Several regulatory domains, including a pseudokinase domain, a histidyl-tRNA synthetase (HisRS)-related region, and a C-term...

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Udgivet i:Mol Cell Biol
Principais autores: Qiu, Hongfang, Garcia-Barrio, Minerva T., Hinnebusch, Alan G.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110649/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9566889/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.5.2697
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