Assembly of T-Antigen Double Hexamers on the Simian Virus 40 Core Origin Requires Only a Subset of the Available Binding Sites

Initiation of simian virus 40 (SV40) DNA replication is dependent upon the assembly of two T-antigen (T-ag) hexamers on the SV40 core origin. To further define the oligomerization mechanism, the pentanucleotide requirements for T-ag assembly were investigated. Here, we demonstrate that individual pe...

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Bibliografiska uppgifter
Huvudupphovsmän: Joo, Woo S., Kim, Henry Y., Purviance, John D., Sreekumar, K. R., Bullock, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 1998
Ämnen:
DNA Dynamics and Chromosome Structure
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC110647/
https://ncbi.nlm.nih.gov/pubmed/9566887
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