DNA Immunization with Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination

Our previous studies have shown that isolated cytotoxic T lymphocyte (CTL), B-cell, and T-helper epitopes, for which we coined the term minigenes, can be effective vaccines; when expressed from recombinant vaccinia viruses, these short immunogenic sequences confer protection against a variety of vir...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Rodriguez, Fernando, An, Ling Ling, Harkins, Stephanie, Zhang, Jie, Yokoyama, Masayuki, Widera, Georg, Fuller, James T., Kincaid, Carrie, Campbell, Iain L., Whitton, J. Lindsay
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1998
Fag:	Viral Pathogenesis and Immunity
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110091/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573289/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.6.5174-5181.1998
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