DNA Immunization with Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination

Our previous studies have shown that isolated cytotoxic T lymphocyte (CTL), B-cell, and T-helper epitopes, for which we coined the term minigenes, can be effective vaccines; when expressed from recombinant vaccinia viruses, these short immunogenic sequences confer protection against a variety of vir...

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Detalhes bibliográficos
Main Authors: Rodriguez, Fernando, An, Ling Ling, Harkins, Stephanie, Zhang, Jie, Yokoyama, Masayuki, Widera, Georg, Fuller, James T., Kincaid, Carrie, Campbell, Iain L., Whitton, J. Lindsay
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110091/
https://ncbi.nlm.nih.gov/pubmed/9573289
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