Structure-Based Mutational Analysis of the C-Terminal DNA-Binding Domain of Human Immunodeficiency Virus Type 1 Integrase: Critical Residues for Protein Oligomerization and DNA Binding
The C-terminal domain of human immunodeficiency virus type 1 (HIV-1) integrase (IN) is a dimer that binds to DNA in a nonspecific manner. The structure of the minimal region required for DNA binding (IN(220–270)) has been solved by nuclear magnetic resonance spectroscopy. The overall fold of the C-t...
Guardat en:
| Publicat a: | J Virol |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110031/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573250/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.6.4841-4848.1998 |
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