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Structure-Based Mutational Analysis of the C-Terminal DNA-Binding Domain of Human Immunodeficiency Virus Type 1 Integrase: Critical Residues for Protein Oligomerization and DNA Binding

The C-terminal domain of human immunodeficiency virus type 1 (HIV-1) integrase (IN) is a dimer that binds to DNA in a nonspecific manner. The structure of the minimal region required for DNA binding (IN(220–270)) has been solved by nuclear magnetic resonance spectroscopy. The overall fold of the C-t...

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Autors principals: Lutzke, Ramon A. Puras, Plasterk, Ronald H. A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC110031/
https://ncbi.nlm.nih.gov/pubmed/9573250
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