Resistance of Human Cytomegalovirus to Benzimidazole Ribonucleosides Maps to Two Open Reading Frames: UL89 and UL56

2,5,6-Trichloro-1-β-d-ribofuranosyl benzimidazole (TCRB) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication. TCRB acts via a novel mechanism involving inhibition of viral DNA processing and packaging. Resistance to the 2-bromo analog (BDCRB) has been mapped to the UL89 o...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Krosky, Paula M., Underwood, Mark R., Turk, Steven R., Feng, Kathryne W.-H., Jain, Rajeev K., Ptak, Roger G., Westerman, Allison C., Biron, Karen K., Townsend, Leroy B., Drach, John C.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Assuntos:	Animal Viruses
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110001/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.6.4721-4728.1998
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