Resistance of Human Cytomegalovirus to Benzimidazole Ribonucleosides Maps to Two Open Reading Frames: UL89 and UL56

2,5,6-Trichloro-1-β-d-ribofuranosyl benzimidazole (TCRB) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication. TCRB acts via a novel mechanism involving inhibition of viral DNA processing and packaging. Resistance to the 2-bromo analog (BDCRB) has been mapped to the UL89 o...

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Detalhes bibliográficos
Main Authors: Krosky, Paula M., Underwood, Mark R., Turk, Steven R., Feng, Kathryne W.-H., Jain, Rajeev K., Ptak, Roger G., Westerman, Allison C., Biron, Karen K., Townsend, Leroy B., Drach, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Animal Viruses
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110001/
https://ncbi.nlm.nih.gov/pubmed/9573236
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