Combinatorial Blockade of Calcineurin and CD28 Signaling Facilitates Primary and Secondary Therapeutic Gene Transfer by Adenovirus Vectors in Dystrophic (mdx) Mouse Muscles

Recombinant adenovirus vectors (AdV) have been considered a potential vehicle for performing gene therapy in patients suffering from Duchenne muscular dystrophy but are limited by a cellular and humoral immune response that prevents long-term transgene expression as well as effective transduction af...

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Main Authors: Guibinga, Ghiabe-Henri, Lochmuller, Hanns, Massie, Bernard, Nalbantoglu, Josephine, Karpati, George, Petrof, Basil J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Gene Therapy
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC109975/
https://ncbi.nlm.nih.gov/pubmed/9573223
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