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P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment

Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological characteristics of DMD skeletal muscles include, among others, abnormal Ca(2+) homeostasis and cell signalling. Here, in the mdx mouse model of DMD, we demonstrate significant P2X7 receptor abnormalities in isolate...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Young, Christopher N J, Brutkowski, Wojciech, Lien, Chun-Fu, Arkle, Stephen, Lochmüller, Hanns, Zabłocki, Krzysztof, Górecki, Dariusz C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365874/
https://ncbi.nlm.nih.gov/pubmed/21794079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2011.01397.x
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