Attenuation of Influenza A Virus mRNA Levels by Promoter Mutations

We have engineered influenza A/WSN/33 viruses which have viral RNA (vRNA) segments with altered base pairs in the conserved double-stranded region of their vRNA promoters. The mutations were introduced into the segment coding for the neuraminidase (NA) by using a reverse genetics system. Two of the...

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Bibliografske podrobnosti
Main Authors: Fodor, Ervin, Palese, Peter, Brownlee, George G., García-Sastre, Adolfo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Animal Viruses
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC109764/
https://ncbi.nlm.nih.gov/pubmed/9658066
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