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The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity

Variants of human immunodeficiency virus type 1 (HIV-1) that are highly resistant to a number of nucleoside analog drugs have been shown to develop in some patients receiving 2′,3′-dideoxy-3′-azidothymidine therapy in combination with 2′,3′-dideoxycytidine or 2′,3′-dideoxyinosine. The appearance, in...

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Udgivet i:J Virol
Principais autores: Rezende, Lisa F., Curr, Kenneth, Ueno, Takamasa, Mitsuya, Hiroaki, Prasad, Vinayaka R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Animal Viruses
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109734/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9525609/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.4.2890-2895.1998
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