Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations

A 40-amino-acid sequence located in the nonstructural 5A (NS5A) protein of hepatitis C virus genotype 1b (HCV-1b) was recently suggested to be the interferon sensitivity-determining region (ISDR), because HCV-1b strains with an ISDR amino acid sequence identical to that of the prototype strain HCV-J...

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Main Authors: Pawlotsky, Jean-Michel, Germanidis, Georgios, Neumann, Avidan U., Pellerin, Muriel, Frainais, Pierre-Olivier, Dhumeaux, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC109724/
https://ncbi.nlm.nih.gov/pubmed/9525599
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