Three Amino Acid Substitutions in the L Protein of the Human Parainfluenza Virus Type 3 cp45 Live Attenuated Vaccine Candidate Contribute to Its Temperature-Sensitive and Attenuation Phenotypes

Studies were initiated to define the genetic basis of the temperature-sensitive (ts), cold adaptation (ca), and attenuation (att) phenotypes of the human parainfluenza virus type 3 (PIV3) cp45 live attenuated vaccine candidate. Genetic data had previously suggested that the L polymerase protein of c...

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Detalhes bibliográficos
Main Authors: Skiadopoulos, Mario H., Durbin, Anna P., Tatem, Joanne M., Wu, Shin-Lu, Paschalis, Maribel, Tao, Tao, Collins, Peter L., Murphy, Brian R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Animal Viruses
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109464/
https://ncbi.nlm.nih.gov/pubmed/9499025
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