Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes

BACKGROUND: Two recombinant, live attenuated human parainfluenza virus type 1 (rHPIV1) mutant viruses have been developed, using a reverse genetics system, for evaluation as potential intranasal vaccine candidates. These rHPIV1 vaccine candidates have two non-temperature sensitive (non-ts) attenuati...

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Detalhes bibliográficos
Main Authors: Bartlett, Emmalene J, Castaño, Adam, Surman, Sonja R, Collins, Peter L, Skiadopoulos, Mario H, Murphy, Brian R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939843/
https://ncbi.nlm.nih.gov/pubmed/17605811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-67
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