Identification of Mutations Contributing to the Temperature-Sensitive, Cold-Adapted, and Attenuation Phenotypes of the Live-Attenuated Cold-Passage 45 (cp45) Human Parainfluenza Virus 3 Candidate Vaccine

The live-attenuated human parainfluenza virus 3 (PIV3) cold-passage 45 (cp45) candidate vaccine was shown previously to be safe, immunogenic, and phenotypically stable in seronegative human infants. Previous findings indicated that each of the three amino acid substitutions in the L polymerase prote...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Skiadopoulos, Mario H., Surman, Sonja, Tatem, Joanne M., Paschalis, Maribel, Wu, Shin-Lu, Udem, Stephen A., Durbin, Anna P., Collins, Peter L., Murphy, Brian R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103961/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9882342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.2.1374-1381.1999
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