Spontaneous Mutations in the env Gene of the Human Immunodeficiency Virus Type 1 NDK Isolate Are Associated with a CD4-Independent Entry Phenotype

Human immunodeficiency virus type 1 (HIV-1) entry into target cells is a multistep process initiated by envelope protein gp120 binding to cell surface CD4. The conformational changes induced by this interaction likely favor a second-step interaction between gp120 and a coreceptor such as CXCR4 or CC...

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Main Authors: Dumonceaux, Julie, Nisole, Sébastien, Chanel, Chantal, Quivet, Laurence, Amara, Ali, Baleux, Frano̧ise, Briand, Pascale, Hazan, Uriel
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC109402/
https://ncbi.nlm.nih.gov/pubmed/9420253
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