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The Pleckstrin Homology and Phosphotyrosine Binding Domains of Insulin Receptor Substrate 1 Mediate Inhibition of Apoptosis by Insulin

Insulin and insulin-like growth factor 1 (IGF-1) evoke diverse biological effects through receptor-mediated tyrosine phosphorylation of insulin receptor substrate (IRS) proteins. We investigated the elements of IRS-1 signaling that inhibit apoptosis of interleukin 3 (IL-3)-deprived 32D myeloid proge...

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Autors principals: Yenush, Lynne, Zanella, Christine, Uchida, Tohru, Bernal, Dolores, White, Morris F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC109262/
https://ncbi.nlm.nih.gov/pubmed/9774692
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